Beyond Science and Decisions: From Problem Formulation to Dose-Response Assessment



Beyond Science & Decisions > Case Studies

Case studies

 

Use of human data in cancer risk assessment of chemicals as illustrated by the case of 1,3-Butadiene
Albertini R., Sielken Jr. R.L.

Tags:     In-Depth Risk Assessment Mode of Action Assessment Sufficiency of MOA Evidence
Initial Case Study Revised Case Study

Biologically Based Dose Response (BBDR) model for respiratory tract carcinogenicity of inhaled formaldehyde
Allen B., Clewell H., Conolly R., Haney J., Kester J.

Tags: In Depth Risk Assessment Background Exp Assessment Formaldehyde Endog Exp Dose-Resp
Inititial Case Study

Revised Case Study

Biologically-Informed Empirical Dose Response Modeling:  Using Linked Cause-Effect Functions to Extend the Dose-Response Curve to Lower Doses (Titanium dioxide - TiO2) 
Allen B., Maier A., Willis A., Haber L.T.

Tags: In Depth Risk Assessment    

Initial Case Study

Risk Assessment of Exposure to Trihalomethane Drinking Water Disinfection By-Products.  Use of Biomonitoring Equivalents and Biomonitoring Data from NHANES
Aylward L.L., Hays S.M., Kirman C.R., Becker RA

Tags: In Depth Risk Assessment    

Ethanol Case Study – Evaluating Human Dose-Response of Morbidity and Mortality from Hepatic Disease: Are the Predicted Risks from Low-Dose Linear Extrapolation to Environmentally Relevant Concentrations Biologically Plausible?
Becker R., Hays S.

Tags: In Depth Risk Assessment    

Initial Case Study

Revised Case Study

Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data
Becker, Richard A., Sean M. Hays, Steven Robison, Lesa L. Aylward, Christopher R. Kirman

Tags: Qualititative Screening    

 

Sustainable Futures Screening
Becker E., Ranslow P.

Tags: Qualititative Screening    

Initial Case Study

Revised Case Study

Criteria Requirements for Data-Driven Carcinogenicity Mode of Action (MOA) Determinations as Exemplified by Chloroform
Borgert, C.

Tags: In Depth Risk Assessment Mode of Action  

 

The Human Relevant Potency Threshold: Reducing Uncertainty by Human Calibration of Cumulative Risk Assessments
Borgert, C.

Tags: Quantitative Screening    

 

Lead – Dose-response relationship for effect on Children’s IQ
Carrington C.D.

Tags: In-Depth Risk Assessment Dose-Response Model Selection Conceptual Model Other

Risk-Risk Comparison:  Comparative Risk for Use of Perchloroethylene (Perc) or N-propyl-bromide (NPB) in Dry Cleaning
Clewell H., Finkel A.

Tags: In-Depth Risk Assessment Dose-Response Model Selection Conceptual Model Other

Use of Categorical Regression – Risk Above the RfD
Danzeisen R., Krewski D., Chambers A., Baker S., Hertzberg R., and Haber L.

Tags: In-Depth Risk Assessment Dose-Response Model Selection Conceptual Model Other

Initial Case Study

Revised Case Study

Endogenous Formation Implications for Formaldehyde Carcinogenicity
Gentry R., Starr T., Swenberg J., Schroeter J.

Tags: In Depth Risk Assessment    

Initial Case Study

 

Use of biomarkers in the benchmark dose method
Gentry R., Van Landingham C., Hays S., Aylward L.

Tags: In Depth Risk Assessment    

Initial Case Study

Revised Case Study

Apply AEGL Methodology to Develop Acute Exposure Guideline Levels for Ethylbenzene
Grant R., Erraguntla N., Hinz J., Camacho I.A.

Tags: In-Depth Risk Assessment Dose-Response Model Selection Conceptual Model

Initial Case Study

Revised Case Study

 

Interpretation of 24-hour Sampling Data – Texas Commission on Environmental Quality Approach
Grant R., Jenkins A., Haney J.

Tags: In Depth Risk Assessment    

Initial Case Study

Revised Case Study

Deriving Health-Protective Values for Evaluation of Acute Inhalation Exposures for Chemicals with Limited Toxicity Data Using a Tiered Screening Approach 
Grant R.L., Phillips T., Ethridge S.

Tags: Quantitative Assessment    

Initial Case Study

 

Methods for Deriving Inhalation Effect Levels for Comparison to Health-Protective Values 
Grant, R., Jenkins, A., Haney, J.

Tags: In Depth Risk Assessment    

Revised Case Study

 

Comparison of Hattis strawman approach and BMDs/UFs for noncancer endpoints (carbonyl sulfide and tetrachlorobenzene)
Greco S.L., Hattis D.H., Lynch M.K.

Tags: In Depth Risk Assessment Dose Response Model Selection  

Multiple modes of action and risk assessment modeling
Hertzberg R.
Advisor: Dourson M.

Tags: In Depth Risk Assessment Mode of Action  

Initial Case Study

Quantitative Assessment of Sensitivity and Variability in Humans: Modeling the Effects of Low Dose Exposure to Dietary Residues of Chlorpyrifos   
Juberg D.R., Price P.

Tags: In Depth Risk Assessment    

The Quantitative Human Health Risk Assessment for 1,3-Butadiene Based Upon Ovarian Effects in Rodents
Kirman C.R., Grant R.L.

Tags: In Depth Risk Assessment    

Initial Case Study

Revised Case Study

Implications of Linear Low-Dose Extrapolation from Benchmark Dose for Noncancer Risk Assessment 
Kroner O., Haber L.
Advisor: Dourson M.

Tags: Qualitative Screening    
Initial Case Study Revised Case Study

Consideration of Human Kinetic Variability
Lipscomb J.C., Teuschler L.K., Swartout J., Popken D., Cox T., Kedderis G.L.

Tags: In Depth Risk Assessment    

Initial Case Study

Framework for Evaluating Alternative Temporal Patterns of Exposure for Risk Characterization
Maier A., Haber L., Haney J., Kaden D.A., Carrier R., Craft E., and Hertzberg R.
Advisor: Dourson, M.

Tags: In Depth Risk Assessment    
Initial Case Study

Revised Case Study

 

Review and application of data fusion methodologies for toxicological dataset analysis to resolve data quality issues in predictive toxicology and contaminated sites risk assessment.
Mohapatra A.K., Sadiq R., Zargar A., Islam S., Dyck R.

Tags: In Depth Risk Assessment    

Initial Case Study

Revised Case Study

 

Assessment of Low-Dose Dose-Response Relationships (Non-linear or Linear) for Genotoxicity, Focused on Induction of Mutations & Clastogenic Effects
Moore M., Pottenger L., Zeiger E., and Zhou T.

Tags: In Depth Risk Assessment    

Initial Case Study

Revised Case Study

Background/Endogenous Damage: Considerations for Dose-Response & Risk Assessment 
Pottenger L.H., Bus J.S., with support from J.A. Swenberg

Tags: In depth Risk Assessment    

Value of Information: Approach and Case Studies 
Eric Ruder, Henry Roman

Tags: Qualitative Risk Assessment    

 

Interpretation of 24-hour sampling data: Development of 24-hour ambient air quality criteria and their use in Ontario
Schroeder J., Jugloff D.

Tags: Qualitative Risk Assessment    

Intial Case Study

Application of National Research Council “Silverbook” Methodology for Dose Response Assessment of 2,3,7,8-Tetrachlorodibenzo(p)dioxin.
Simon T., Stephens M., Yang Y., Manning R.O., Budinsky R.A. and Rowlands J.C.

Tags: In Depth RA    

Intial Case Study

Revised Case Study

Estimate Risk Above the RfD Using Uncertainty Factor Distributions 
Spalt E., Kroner O.
Advisor: Dourson M.

Tags: In-Depth RA Dose-Response Model Selection Small Data Requirements

Initial Case Study

Revised Case Study

 

For more information, please contact Oliver Kroner.

 

 

 

Workshop Collaborators

SOT

Texas Commission on Environmental Quality

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TERA

EPA
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3

Noblis Logo

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IDEM Logo

6

5

Georgia
                                           
8

New Zealand Ministry of Health (Manatu Hauora)

9      
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1

2

3

4

mpca-horiz-left

FDA, U S Food and Drug Administration

2

Department of Health

5

1

Ohio EPA logo

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Texas Chem Council

NIPERA

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nctr

Summit

Environ

EPRI