What is
Dose-Response
Assessment Boot
Camp?
It is a new
initiative
providing
intensive,
in-depth
hands-on
training in
hazard
characterization
and
dose-response
assessment for
human health
risk
assessments.
This week-long
course with
emphasis on dose
response
assessment is
based on our
popular chemical
risk assessment
training
sessions
developed and
presented to
various
audiences in the
past decade. It
is designed to
provide
systematic
training in
current
assessment
practices as
well as in the
latest methods
in human health
chemical risk
assessments.
The course is
for beginners
through
experienced
toxicological
risk assessors
who wish to
learn advanced
methods and
enhance their
understanding
and skills in
the basics. The
students will
learn all
aspects of
hazard
characterization
and dose
response
assessment, and
practice the
skills learned
in the
classroom.
Upon completing
the course, the
participants
will be able to
derive and
evaluate risk
values and
supporting
documentation
for non-cancer
and cancer risk
assessments and
will receive a
certificate
documenting
their successful
completion of
the course.
Five
Certification
Management (CM)
points are
available from
the American
Board of
Industrial
Hygienists (ABIH).
Current
Courses
Who should
attend?
-
Risk
assessors
and
toxicologists
who conduct
and write
chemical
assessments
-
Risk
assessors
and
toxicologists
who review
chemical
assessments
-
Risk
managers or
policymakers
who use the
results of
chemical
assessments
and want to
fully
understand
the
processes
involved in
risk value
development
Participant
requirements -
participants
should have:
-
A basic
understanding
of
toxicology
-
An interest
in
developing
their skills
in human
health risk
assessment
What you
will learn
1.
Non-cancer and
Cancer Risk
Assessment
Principles and
Methods:
Learn how to
critically
analyze effect
data, understand
toxicokinetic
data and their
use in
understanding
mode of action
(MOA) and
developing risk
values. Learn
how to
incorporate
uncertainty
factors, utilize
frameworks for
considering MOA
and human
relevance, and
learn
information
synthesis
approaches for
hazard
characterization
and critical
study
identification,
and calculation
of risk values
for non-cancer
(e.g., reference
doses or
tolerable
intakes) and
cancer endpoints
(e.g., cancer
slope factors).
Learn the latest
methodologies
used in
dose-response
assessment.
2.
Dosimetric
Adjustment
Methods in Dose
Response:
Learn how to
develop
interspecies
oral dose
adjustments for
non-cancer and
cancer
assessment,
cancer unit risk
or slope factor
conversion,
inhalation
exposure
concentration
unit conversion,
and human
equivalent
concentration (HEC)
calculation for
particle and
vapor exposure
using various
modeling
approaches.
Applications of
the results of
physiologically-based
pharmacokinetic
(PBPK) modeling
will also be
introduced.
3.
Benchmark Dose (BMD)
Modeling and
Application in
Risk
Assessment:
Learn how to do
BMD modeling for
non-cancer and
cancer
dose-response
assessments and
get hands-on
experience using
the latest EPA
software. Learn
how to
appropriately
apply BMD
modeling, choose
models and
parameters,
select data and
run models, and
select the
appropriate BMD
as a point of
departure in a
human health
risk
assessment. The
course addresses
all of the
models in the
EPA software,
including
dichotomous
continuous,
cancer, and
nested models.
4.
Principles for
the Application
of Uncertainty
Factors and
Chemical
Specific
Adjustment
Factor (CSAF)
Methodology:
Learn the
concept of
uncertainty
factors and how
they are used in
non-cancer risk
and safety
assessment by
USEPA and other
organizations,
and how data are
used to
support values
other than
defaults. Learn
how to develop
and use CSAFs
according to the
methods of the
International
Programme on
Chemical Safety
(IPCS), which
includes the use
of mechanistic
and
toxicokinetic
data to replace
default
uncertainty
factors for
interspecies
extrapolation
and intraspecies
variability in
deriving risk
values such as
RfDs and
Tolerable
Concentrations (TCs).
5.
Comprehensive
Risk Assessment
Practice with
Peer Review:
Learn to
develop, present
and review a
comprehensive
non-cancer and
cancer
assessment for a
complex sample
chemical over
the course of
the entire week.
Look
at the
Frequently Asked
Questions
for more details
or
for more
information,
please contact
Ms. Patricia
Nance at
513-542-7475 x25
or
nance@tera.org
or for specific
course content
contact Dr.
Lynne Haber at
513-542-7475 x
17 or
haber@tera.org.
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